We present a new model for fanning and bending white matter structures on a sub-voxel scale. We devise a parametric model of how the fibre orientation varies spatially over each sub-voxel in the voxel grid for both types of configuration. Fitting the model provides quantitative information about the degree of fanning or bending in each voxel. We demonstrate using data from a standard human brain diffusion MRI acquisition.

Author: Shahrum Nedjati-Gilani
Author: Daniel C. Alexander

Publication: International Society For Magnetic Resonance In Medicine (ISMRM) | full text (PDF)

Publication URL: http://www.cs.ucl.ac.uk/miccai/dmfc/orals/paper27.pdf

Year: 2009

Diffusion MRI provides an insight into the microstructural architecture of tissue by observing the restricted and hindered displacement of water molecules undergoing Brownian motion in vivo. By looking at the probability density function p of displacements over a fixed period of time t, inferences can be made about the tissue microstructure.

Author: Geoff J. M. Parker
Author: Daniel C. Alexander
Author: Shahrum Nedjati-Gilani

Publication: IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI) ( pp.875-878). | full text (PDF)

Year: 2008